Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant

Barbara Bottazzi; Laura Santini; Silvana Savino; Marzia M. Giuliani; Ana I. Dueñas Díez; Giuseppe Mancuso; Concetta Beninati; Marina Sironi; Sonia Valentino; Livija Deban; Cecilia Garlanda; Giuseppe Teti; Mariagrazia Pizza; Rino Rappuoli; Alberto Mantovani

doi:10.1371/journal.pone.0120807

Loading metrics

Open Access

Peer-reviewed

Research Article

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant

Barbara Bottazzi ,

* E-mail: barbara.bottazzi@humanitasresearch.it

Affiliation Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy
⨯
Laura Santini,

Affiliation Novartis Vaccines and Diagnostics Research Center, Siena, Italy
⨯
Silvana Savino,

Affiliation Novartis Vaccines and Diagnostics Research Center, Siena, Italy
⨯
Marzia M. Giuliani,

Affiliation Novartis Vaccines and Diagnostics Research Center, Siena, Italy
⨯
Ana I. Dueñas Díez,

Affiliation Unidad de Investigación. Hospital Clínico Universitario, Valladolid, Spain
⨯
Giuseppe Mancuso,

Affiliation Metchnikoff Laboratory, University of Messina, Messina, Italy
⨯
Concetta Beninati,

Affiliation Metchnikoff Laboratory, University of Messina, Messina, Italy
⨯
Marina Sironi,

Affiliation Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy
⨯
Sonia Valentino,

Affiliation Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy
⨯
Livija Deban,

Current address: Cancer Research UK, London Research Institute, London, United Kingdom

Affiliation Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy
⨯
Cecilia Garlanda,

Affiliation Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy
⨯
Giuseppe Teti,

Affiliation Metchnikoff Laboratory, University of Messina, Messina, Italy
⨯
Mariagrazia Pizza,

Affiliation Novartis Vaccines and Diagnostics Research Center, Siena, Italy
⨯
Rino Rappuoli,

Affiliation Novartis Vaccines and Diagnostics Research Center, Siena, Italy
⨯
Alberto Mantovani

Affiliations Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy, Humanitas University, Rozzano (Milan), Italy
⨯

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant

Barbara Bottazzi,
Laura Santini,
Silvana Savino,
Marzia M. Giuliani,
Ana I. Dueñas Díez,
Giuseppe Mancuso,
Concetta Beninati,
Marina Sironi,
Sonia Valentino,
Livija Deban

Published: March 18, 2015
https://doi.org/10.1371/journal.pone.0120807

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neisseria meningitidis
Is the Subject Area "Neisseria meningitidis" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Complement system
Is the Subject Area "Complement system" applicable to this article?

Thanks for your feedback.
Recombinant proteins
Is the Subject Area "Recombinant proteins" applicable to this article?

Thanks for your feedback.
C-reactive proteins
Is the Subject Area "C-reactive proteins" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Innate immune system
Is the Subject Area "Innate immune system" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.