YAP Enhances Autophagic Flux to Promote Breast Cancer Cell Survival in Response to Nutrient Deprivation

Qinghe Song; Beibei Mao; Jinbo Cheng; Yuhao Gao; Ke Jiang; Jun Chen; Zengqiang Yuan; Songshu Meng

doi:10.1371/journal.pone.0120790

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Open Access

Peer-reviewed

Research Article

YAP Enhances Autophagic Flux to Promote Breast Cancer Cell Survival in Response to Nutrient Deprivation

Qinghe Song,

Affiliations State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
⨯
Beibei Mao,

Affiliation State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
⨯
Jinbo Cheng,

Affiliation State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
⨯
Yuhao Gao,

Affiliations State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
⨯
Ke Jiang,

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, Liaoning, China
⨯
Jun Chen,

Affiliation Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu, China
⨯
Zengqiang Yuan ,

* E-mail: zqyuan@ibp.ac.cn (ZY); ssmeng@dlmedu.edu.cn (SM)

Affiliations State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
⨯
Songshu Meng

* E-mail: zqyuan@ibp.ac.cn (ZY); ssmeng@dlmedu.edu.cn (SM)

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, Liaoning, China
⨯

YAP Enhances Autophagic Flux to Promote Breast Cancer Cell Survival in Response to Nutrient Deprivation

Qinghe Song,
Beibei Mao,
Jinbo Cheng,
Yuhao Gao,
Ke Jiang,
Jun Chen,
Zengqiang Yuan,
Songshu Meng

Published: March 26, 2015
https://doi.org/10.1371/journal.pone.0120790

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Autophagic cell death
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Breast cancer
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Apoptosis
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MTT assay
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Cancer treatment
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