Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences

Emily M. Eriksson; Teri Liegler; Chris E. Keh; Annika C. Karlsson; Sara J. Holditch; Christopher D. Pilcher; Lisa Loeb; Douglas F. Nixon; Frederick M. Hecht

doi:10.1371/journal.pone.0120787

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Open Access

Peer-reviewed

Research Article

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences

Emily M. Eriksson ,

* E-mail: eriksson@wehi.edu.au

Current address: Walter and Eliza Hall Institute of Medical Science and University of Melbourne, Department of Medical Biology, Melbourne, Australia

Affiliation Division of Experimental Medicine, Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Teri Liegler,

Affiliation Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Chris E. Keh,

Affiliation Division of Experimental Medicine, Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Annika C. Karlsson,

Affiliation Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden
⨯
Sara J. Holditch,

Affiliation Division of Experimental Medicine, Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Christopher D. Pilcher,

Affiliation Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Lisa Loeb,

Affiliation Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Douglas F. Nixon,

Current address: The GW School of Medicine and Health Sciences, Washington DC, United States of America

Affiliation Division of Experimental Medicine, Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯
Frederick M. Hecht

Affiliation Department of Medicine, University of California, San Francisco Positive Health Program, San Francisco General Hospital, San Francisco, California
⨯

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences

Emily M. Eriksson,
Teri Liegler,
Chris E. Keh,
Annika C. Karlsson,
Sara J. Holditch,
Christopher D. Pilcher,
Lisa Loeb,
Douglas F. Nixon,
Frederick M. Hecht

Published: April 28, 2015
https://doi.org/10.1371/journal.pone.0120787

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T cells
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HIV-1
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Microbial mutation
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RNA sequencing
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