Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid

Faten Shaeib; Sana N. Khan; Iyad Ali; Tohid Najafi; Dhiman Maitra; Ibrahim Abdulhamid; Ghassan M. Saed; Subramaniam Pennathur; Husam M. Abu-Soud

doi:10.1371/journal.pone.0120737

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Peer-reviewed

Research Article

Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid

Faten Shaeib,

Affiliation Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Sana N. Khan,

Affiliation Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Iyad Ali,

Affiliations Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Biochemistry and Genetics, Faculty of Medicine, An-Najah National University, Nablus, Palestine
⨯
Tohid Najafi,

Affiliations Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Dhiman Maitra,

Affiliation Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Ibrahim Abdulhamid,

Affiliation Children’s Hospital of Michigan, Detroit, Michigan
⨯
Ghassan M. Saed,

Affiliation Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Subramaniam Pennathur,

Affiliation Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Husam M. Abu-Soud

* E-mail: habusoud@med.wayne.edu

Affiliations Departments of Obstetrics and Gynecology, the C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯

Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid

Faten Shaeib,
Sana N. Khan,
Iyad Ali,
Tohid Najafi,
Dhiman Maitra,
Ibrahim Abdulhamid,
Ghassan M. Saed,
Subramaniam Pennathur,
Husam M. Abu-Soud

Published: April 2, 2015
https://doi.org/10.1371/journal.pone.0120737

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Heme
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Melatonin
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Oxidation
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