Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

Thomas Schweiger; Christoph Nikolowsky; Patrick Starlinger; Denise Traxler; Matthias Zimmermann; Peter Birner; Balazs Hegedüs; Balazs Dome; Michael Bergmann; Michael Mildner; Walter Klepetko; Konrad Hoetzenecker; Hendrik Jan Ankersmit

doi:10.1371/journal.pone.0120724

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Open Access

Peer-reviewed

Research Article

Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

Thomas Schweiger,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯
Christoph Nikolowsky,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯
Patrick Starlinger,

Affiliation Department of General Surgery, Medical University of Vienna, Vienna, Austria
⨯
Denise Traxler,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯
Matthias Zimmermann,

Affiliation Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯
Peter Birner,

Affiliations Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
⨯
Balazs Hegedüs,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary, Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria
⨯
Balazs Dome,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, National Koranyi Institute of Pulmonology, Budapest, Hungary, Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary, Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria
⨯
Michael Bergmann,

Affiliation Department of General Surgery, Medical University of Vienna, Vienna, Austria
⨯
Michael Mildner,

Affiliation Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Walter Klepetko,

Affiliation Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
⨯
Konrad Hoetzenecker,

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯
Hendrik Jan Ankersmit

* E-mail: hendrik.ankersmit@meduniwien.ac.at

Affiliations Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria
⨯

Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

Thomas Schweiger,
Christoph Nikolowsky,
Patrick Starlinger,
Denise Traxler,
Matthias Zimmermann,
Peter Birner,
Balazs Hegedüs,
Balazs Dome,
Michael Bergmann,
Michael Mildner

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120724

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Metastasis
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Colorectal cancer
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Lung and intrathoracic tumors
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Non-small cell lung cancer
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Secondary lung tumors
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Cell staining
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Hepatocellular carcinoma
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