Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response

Wei-dong Qin; Shao-hua Mi; Chen Li; Gui-xia Wang; Jian-ning Zhang; Hao Wang; Fan Zhang; Yang Ma; Da-wei Wu; Mingxiang Zhang

doi:10.1371/journal.pone.0120586

Loading metrics

Open Access

Peer-reviewed

Research Article

Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response

Wei-dong Qin ,

Contributed equally to this work with: Wei-dong Qin, Shao-hua Mi, Chen Li

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Shao-hua Mi ,

Contributed equally to this work with: Wei-dong Qin, Shao-hua Mi, Chen Li

Affiliation The Department of Cardiology, Yu Huang Ding Hospital, Yantai, Shandong, China,
⨯
Chen Li ,

Contributed equally to this work with: Wei-dong Qin, Shao-hua Mi, Chen Li

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Gui-xia Wang,

Affiliation The Department of Radiology, Linyi People’s Hospital, Linyi, Shandong, China
⨯
Jian-ning Zhang,

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Hao Wang,

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Fan Zhang,

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Yang Ma,

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Da-wei Wu ,

* E-mail: season__202@163.com (MZ), wdw.55@163.com (DW)

Affiliation The Department of Critical Care Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Mingxiang Zhang

* E-mail: season__202@163.com (MZ), wdw.55@163.com (DW)

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯

Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response

Wei-dong Qin,
Shao-hua Mi,
Chen Li,
Gui-xia Wang,
Jian-ning Zhang,
Hao Wang,
Fan Zhang,
Yang Ma,
Da-wei Wu,
Mingxiang Zhang

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120586

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Protein secretion
Is the Subject Area "Protein secretion" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Atherosclerosis
Is the Subject Area "Atherosclerosis" applicable to this article?

Thanks for your feedback.
Shear stresses
Is the Subject Area "Shear stresses" applicable to this article?

Thanks for your feedback.