Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results from 24 Clones Derived from a Single C57BL/6 Mouse

Cheng Li; Jeffery M. Klco; Nichole M. Helton; Daniel R. George; Jacqueline L. Mudd; Christopher A. Miller; Charles Lu; Robert Fulton; Michelle O'Laughlin; Catrina Fronick; Richard K. Wilson; Timothy J. Ley

doi:10.1371/journal.pone.0120585

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Open Access

Peer-reviewed

Research Article

Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results from 24 Clones Derived from a Single C57BL/6 Mouse

Cheng Li,

Current address: Onyx Pharmaceuticals, Inc., South San Francisco, California, United States of America

Affiliation Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jeffery M. Klco,

Current address: St Jude Children’s Research Hospital, Memphis, TN, United States of America

Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Nichole M. Helton,

Affiliation Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Daniel R. George,

Affiliation Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jacqueline L. Mudd,

Affiliation Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Christopher A. Miller,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Charles Lu,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Robert Fulton,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Michelle O'Laughlin,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Catrina Fronick,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Richard K. Wilson,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Timothy J. Ley

* E-mail: timley@wustl.edu

Affiliation Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results from 24 Clones Derived from a Single C57BL/6 Mouse

Cheng Li,
Jeffery M. Klco,
Nichole M. Helton,
Daniel R. George,
Jacqueline L. Mudd,
Christopher A. Miller,
Charles Lu,
Robert Fulton,
Michelle O'Laughlin,
Catrina Fronick

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0120585

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