Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

Galen W. Heyne; Cal G. Melberg; Padydeh Doroodchi; Kia F. Parins; Henry W. Kietzman; Joshua L. Everson; Lydia J. Ansen-Wilson; Robert J. Lipinski

doi:10.1371/journal.pone.0120517

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Peer-reviewed

Research Article

Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

Galen W. Heyne,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Cal G. Melberg,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Padydeh Doroodchi,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Kia F. Parins,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Henry W. Kietzman,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Joshua L. Everson,

Affiliations Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States of America
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Lydia J. Ansen-Wilson,

Affiliation Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America
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Robert J. Lipinski

* E-mail: rjlipinski@wisc.edu

Affiliations Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States of America
⨯

Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

Galen W. Heyne,
Cal G. Melberg,
Padydeh Doroodchi,
Kia F. Parins,
Henry W. Kietzman,
Joshua L. Everson,
Lydia J. Ansen-Wilson,
Robert J. Lipinski

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120517

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Hedgehog signaling
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