1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients

Haihua Yang; Feng Long; Youzhi Zhang; Ronghuan Yu; Peng Zhang; Wenjing Li; Shuijun Li; Xianqiao Jin; Jingwen Xia; Liang Dong; Ning Zhu; Ying Huang; Yi Gong; Xiaodong Chen

doi:10.1371/journal.pone.0120515

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Open Access

Peer-reviewed

Research Article

1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients

Haihua Yang,

Affiliation Department of Respiratory Medicine, Huashan Hospital North, Fudan University, ShangHai, China
⨯
Feng Long,

Affiliation Department of Respiratory Medicine, Huashan Hospital North, Fudan University, ShangHai, China
⨯
Youzhi Zhang,

Affiliation Department of Respiratory Medicine, Huashan Hospital North, Fudan University, ShangHai, China
⨯
Ronghuan Yu,

Affiliation Department of Respiratory Medicine, Xuhui Central Hospital, ShangHai, China
⨯
Peng Zhang,

Affiliation Department of Respiratory Medicine, Huashan Hospital North, Fudan University, ShangHai, China
⨯
Wenjing Li,

Affiliation Department of Respiratory Medicine, Huashan Hospital North, Fudan University, ShangHai, China
⨯
Shuijun Li,

Affiliation Department of Central Laboratory, Xuhui Central Hospital, ShangHai, China
⨯
Xianqiao Jin,

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯
Jingwen Xia,

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯
Liang Dong,

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯
Ning Zhu,

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯
Ying Huang,

Affiliation Department of Respiratory Medicine, Xuhui Central Hospital, ShangHai, China
⨯
Yi Gong ,

* E-mail: gongyi1978@hotmail.com (YG); xiaodongchendoctor@163.com (XDC)

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯
Xiaodong Chen

* E-mail: gongyi1978@hotmail.com (YG); xiaodongchendoctor@163.com (XDC)

Affiliation Department of Respiratory Medicine, Huashan Hospital, Fudan University, ShangHai, China
⨯

1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients

Haihua Yang,
Feng Long,
Youzhi Zhang,
Ronghuan Yu,
Peng Zhang,
Wenjing Li,
Shuijun Li,
Xianqiao Jin,
Jingwen Xia,
Liang Dong

Published: April 23, 2015
https://doi.org/10.1371/journal.pone.0120515

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Neutrophils
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Apoptosis
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Chronic obstructive pulmonary disease
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Blood
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MAPK signaling cascades
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Vitamin D
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Flow cytometry
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Inflammatory diseases
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