Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors

Fabio Bucchieri; Antonella Marino Gammazza; Alessandro Pitruzzella; Alberto Fucarino; Felicia Farina; Peter Howarth; Stephen T. Holgate; Giovanni Zummo; Donna E. Davies

doi:10.1371/journal.pone.0120510

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Research Article

Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors

Fabio Bucchieri,

Affiliations Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom, Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy, Institute of Biomedicine and Molecular Immunology (IBIM), Italian National Research Council (CNR), Palermo, Italy
⨯
Antonella Marino Gammazza,

Affiliations Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy
⨯
Alessandro Pitruzzella,

Affiliations Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy
⨯
Alberto Fucarino,

Affiliations Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy
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Felicia Farina,

Affiliation Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy
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Peter Howarth,

Affiliations Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom, Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom
⨯
Stephen T. Holgate,

Affiliations Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom, Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom
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Giovanni Zummo,

Affiliation Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC), University of Palermo, Palermo, Italy
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Donna E. Davies

* E-mail: donnad@soton.ac.uk

Affiliations Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom, Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom
⨯

Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors

Fabio Bucchieri,
Antonella Marino Gammazza,
Alessandro Pitruzzella,
Alberto Fucarino,
Felicia Farina,
Peter Howarth,
Stephen T. Holgate,
Giovanni Zummo,
Donna E. Davies

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120510

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Asthma
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Apoptosis
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Antioxidants
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Smoking habits
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Mitochondria
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Epithelial cells
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Cell death
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Smoking related disorders
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