Differential Subcellular Localization Renders HAI-2 a Matriptase Inhibitor in Breast Cancer Cells but Not in Mammary Epithelial Cells

Hsiang-Hua D. Chang; Yuan Xu; Hongyu Lai; Xiaoyu Yang; Chun-Che Tseng; Ying-Jung J. Lai; Yu Pan; Emily Zhou; Michael D. Johnson; Jehng-Kang Wang; Chen-Yong Lin

doi:10.1371/journal.pone.0120489

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Open Access

Peer-reviewed

Research Article

Differential Subcellular Localization Renders HAI-2 a Matriptase Inhibitor in Breast Cancer Cells but Not in Mammary Epithelial Cells

Hsiang-Hua D. Chang,

Affiliations Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America, Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
⨯
Yuan Xu,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Hongyu Lai,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Xiaoyu Yang,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Chun-Che Tseng,

Affiliations Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America, Department of Biology, Carleton College, Northfield, MN, 55057, United States of America
⨯
Ying-Jung J. Lai,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Yu Pan,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Emily Zhou,

Affiliation Thomas Jefferson High School for Science and Technology, Alexandria, VA, 22046, United States of America
⨯
Michael D. Johnson,

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯
Jehng-Kang Wang ,

* E-mail: jkwang@ndmctsgh.edu.tw

Affiliation Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
⨯
Chen-Yong Lin

Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University Washington, DC, 20057, United States of America
⨯

Differential Subcellular Localization Renders HAI-2 a Matriptase Inhibitor in Breast Cancer Cells but Not in Mammary Epithelial Cells

Hsiang-Hua D. Chang,
Yuan Xu,
Hongyu Lai,
Xiaoyu Yang,
Chun-Che Tseng,
Ying-Jung J. Lai,
Yu Pan,
Emily Zhou,
Michael D. Johnson,
Jehng-Kang Wang

Published: March 18, 2015
https://doi.org/10.1371/journal.pone.0120489

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Zymogens
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