A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms

Praveen K. Vayalil; Joo-Yeun Oh; Fen Zhou; Anne R. Diers; M. Ryan Smith; Hafez Golzarian; Patsy G. Oliver; Robin A. J. Smith; Michael P. Murphy; Sadanandan E. Velu; Aimee Landar

doi:10.1371/journal.pone.0120460

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Peer-reviewed

Research Article

A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms

Praveen K. Vayalil,

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Joo-Yeun Oh,

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Fen Zhou,

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Anne R. Diers,

Current address: Berg, Framingham, Massachusetts, United States of America

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
M. Ryan Smith,

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Hafez Golzarian,

Affiliation Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Patsy G. Oliver,

Affiliation Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Robin A. J. Smith,

Affiliation Department of Chemistry, University of Otago, Dunedin, New Zealand
⨯
Michael P. Murphy,

Affiliation MRC Mitochondrial Biology Unit, Cambridge, United Kingdom
⨯
Sadanandan E. Velu,

Affiliation Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Aimee Landar

* E-mail: landar@uab.edu

Affiliations Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms

Praveen K. Vayalil,
Joo-Yeun Oh,
Fen Zhou,
Anne R. Diers,
M. Ryan Smith,
Hafez Golzarian,
Patsy G. Oliver,
Robin A. J. Smith,
Michael P. Murphy,
Sadanandan E. Velu

Published: March 18, 2015
https://doi.org/10.1371/journal.pone.0120460

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