Dihydroartemisinin Inhibits Glucose Uptake and Cooperates with Glycolysis Inhibitor to Induce Apoptosis in Non-Small Cell Lung Carcinoma Cells

Yan-jun Mi; Guo-jun Geng; Zheng-zhi Zou; Jing Gao; Xian-yang Luo; Yu Liu; Ning Li; Chun-lei Li; Yu-qiang Chen; Xiu-yi Yu; Jie Jiang

doi:10.1371/journal.pone.0120426

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Peer-reviewed

Research Article

Dihydroartemisinin Inhibits Glucose Uptake and Cooperates with Glycolysis Inhibitor to Induce Apoptosis in Non-Small Cell Lung Carcinoma Cells

Yan-jun Mi ,

Contributed equally to this work with: Yan-jun Mi, Guo-jun Geng, Zheng-zhi Zou

Affiliations Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China, Department of Medical Oncology, Chenggong Hospital of Xiamen University, Xiamen, China
⨯
Guo-jun Geng ,

Contributed equally to this work with: Yan-jun Mi, Guo-jun Geng, Zheng-zhi Zou

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Zheng-zhi Zou ,

Contributed equally to this work with: Yan-jun Mi, Guo-jun Geng, Zheng-zhi Zou

Affiliation MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
⨯
Jing Gao,

Affiliation Department of Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Xian-yang Luo,

Affiliation Department of Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Yu Liu,

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Ning Li,

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Chun-lei Li,

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Yu-qiang Chen,

Affiliation Department of Medical Oncology, Chenggong Hospital of Xiamen University, Xiamen, China
⨯
Xiu-yi Yu ,

* E-mail: Xiuyiyu@126.com (XYY); Jiejiangfy@163.com (JJ)

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Jie Jiang

* E-mail: Xiuyiyu@126.com (XYY); Jiejiangfy@163.com (JJ)

Affiliation Department of thoracic surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯

Dihydroartemisinin Inhibits Glucose Uptake and Cooperates with Glycolysis Inhibitor to Induce Apoptosis in Non-Small Cell Lung Carcinoma Cells

Yan-jun Mi,
Guo-jun Geng,
Zheng-zhi Zou,
Jing Gao,
Xian-yang Luo,
Yu Liu,
Ning Li,
Chun-lei Li,
Yu-qiang Chen,
Xiu-yi Yu

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0120426

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Apoptosis
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Non-small cell lung cancer
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Glucose
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Cancer treatment
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Glucose metabolism
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Glycolysis
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Cell metabolism
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