A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

Fu-Hui Xiao; Yong-Han He; Qi-Gang Li; Huan Wu; Long-Hai Luo; Qing-Peng Kong

doi:10.1371/journal.pone.0120388

Loading metrics

Open Access

Peer-reviewed

Research Article

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

Fu-Hui Xiao ,

Contributed equally to this work with: Fu-Hui Xiao, Yong-Han He

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yong-Han He ,

Contributed equally to this work with: Fu-Hui Xiao, Yong-Han He

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China
⨯
Qi-Gang Li,

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China
⨯
Huan Wu,

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China
⨯
Long-Hai Luo ,

* E-mail: kongqp@mail.kiz.ac.cn (QPK); luolh@genomics.cn (LHL)

Affiliation Beijing Genome Institute at Shenzhen, Shenzhen, China
⨯
Qing-Peng Kong

* E-mail: kongqp@mail.kiz.ac.cn (QPK); luolh@genomics.cn (LHL)

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China
⨯

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

Fu-Hui Xiao,
Yong-Han He,
Qi-Gang Li,
Huan Wu,
Long-Hai Luo,
Qing-Peng Kong

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120388

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Human genomics
Is the Subject Area "Human genomics" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Genetics of disease
Is the Subject Area "Genetics of disease" applicable to this article?

Thanks for your feedback.
Cardiovascular diseases
Is the Subject Area "Cardiovascular diseases" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.