Identification of Genes Transcriptionally Responsive to the Loss of MLL Fusions in MLL-Rearranged Acute Lymphoblastic Leukemia

Marieke H. van der Linden; Lidija Seslija; Pauline Schneider; Emma M. C. Driessen; Patricia Garrido Castro; Dominique J. P. M. Stumpel; Eddy van Roon; Jasper de Boer; Owen Williams; Rob Pieters; Ronald W. Stam

doi:10.1371/journal.pone.0120326

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Open Access

Peer-reviewed

Research Article

Identification of Genes Transcriptionally Responsive to the Loss of MLL Fusions in MLL-Rearranged Acute Lymphoblastic Leukemia

Marieke H. van der Linden,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Lidija Seslija,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Pauline Schneider,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Emma M. C. Driessen,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Patricia Garrido Castro,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Dominique J. P. M. Stumpel,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Eddy van Roon,

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯
Jasper de Boer,

Affiliation Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
⨯
Owen Williams,

Affiliation Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
⨯
Rob Pieters,

Affiliations Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands
⨯
Ronald W. Stam

* E-mail: r.stam@erasmusmc.nl

Affiliation Department of Pediatric Oncology/Hematology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands
⨯

Identification of Genes Transcriptionally Responsive to the Loss of MLL Fusions in MLL-Rearranged Acute Lymphoblastic Leukemia

Marieke H. van der Linden,
Lidija Seslija,
Pauline Schneider,
Emma M. C. Driessen,
Patricia Garrido Castro,
Dominique J. P. M. Stumpel,
Eddy van Roon,
Jasper de Boer,
Owen Williams,
Rob Pieters

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0120326

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Cell fusion
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Gene expression
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Small interfering RNA
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Acute lymphoblastic leukemia
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Leukemia
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DNA transcription
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DNA methylation
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