Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations

Peng Chen; Zheng Liu; Xuejuan Wang; Junhui Peng; Qianqian Sun; Jianzhong Li; Mingxing Wang; Liwen Niu; Zhiyong Zhang; Gang Cai; Maikun Teng; Xu Li

doi:10.1371/journal.pone.0120304

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Research Article

Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations

Peng Chen,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Zheng Liu,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Xuejuan Wang,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Junhui Peng,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Qianqian Sun,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Jianzhong Li,

Affiliation Department of Otolaryngology Head and Neck Surgery, Fuzhou general hospital of Nanjing Command, PLA, Fuzhou 350025, China
⨯
Mingxing Wang,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Liwen Niu,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Zhiyong Zhang,

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Gang Cai ,

* E-mail: sachem@ustc.edu.cn (XL); mkteng@ustc.edu.cn (MT); gcai@ustc.edu.cn (GC)

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Maikun Teng ,

* E-mail: sachem@ustc.edu.cn (XL); mkteng@ustc.edu.cn (MT); gcai@ustc.edu.cn (GC)

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯
Xu Li

* E-mail: sachem@ustc.edu.cn (XL); mkteng@ustc.edu.cn (MT); gcai@ustc.edu.cn (GC)

Affiliations Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China, Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026, People’s Republic of China
⨯

Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations

Peng Chen,
Zheng Liu,
Xuejuan Wang,
Junhui Peng,
Qianqian Sun,
Jianzhong Li,
Mingxing Wang,
Liwen Niu,
Zhiyong Zhang,
Gang Cai

Published: March 17, 2015
https://doi.org/10.1371/journal.pone.0120304

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