Arterial Levels of Oxygen Stimulate Intimal Hyperplasia in Human Saphenous Veins via a ROS-Dependent Mechanism

Binata Joddar; Michael S. Firstenberg; Rashmeet K. Reen; Saradhadevi Varadharaj; Mahmood Khan; Rachel C. Childers; Jay L. Zweier; Keith J. Gooch

doi:10.1371/journal.pone.0120301

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Peer-reviewed

Research Article

Arterial Levels of Oxygen Stimulate Intimal Hyperplasia in Human Saphenous Veins via a ROS-Dependent Mechanism

Binata Joddar,

Current address: Department of Mechanical Engineering, University of Texas at El Paso, El Paso, Texas 79968, United States of America

Affiliations Department of Biomedical Engineering at The Ohio State University, Columbus, OH 43210, United States of America, Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
⨯
Michael S. Firstenberg,

Current address: Department of Surgery (Cardiothoracic), Northeast Ohio Medical University, Akron City Hospital—Summa Health Care System, Akron, OH 44304, United States of America

Affiliation Division of Cardiothoracic Surgery at The Ohio State University, Columbus, OH 43210, United States of America
⨯
Rashmeet K. Reen,

Affiliations Department of Biomedical Engineering at The Ohio State University, Columbus, OH 43210, United States of America, Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
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Saradhadevi Varadharaj,

Affiliation Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
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Mahmood Khan,

Affiliations Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America, Department of Emergency Medicine at The Ohio State University, Columbus, OH 43210, United States of America
⨯
Rachel C. Childers,

Affiliations Department of Biomedical Engineering at The Ohio State University, Columbus, OH 43210, United States of America, Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
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Jay L. Zweier,

Affiliation Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
⨯
Keith J. Gooch

* E-mail: gooch.20@osu.edu

Affiliations Department of Biomedical Engineering at The Ohio State University, Columbus, OH 43210, United States of America, Davis Heart & Lung Research Institute at The Ohio State University, Columbus, OH 43210, United States of America
⨯

Arterial Levels of Oxygen Stimulate Intimal Hyperplasia in Human Saphenous Veins via a ROS-Dependent Mechanism

Binata Joddar,
Michael S. Firstenberg,
Rashmeet K. Reen,
Saradhadevi Varadharaj,
Mahmood Khan,
Rachel C. Childers,
Jay L. Zweier,
Keith J. Gooch

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0120301

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