Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Marek M. Nagiec; Adam P. Skepner; Joseph Negri; Michelle Eichhorn; Nicolas Kuperwasser; Eamon Comer; Giovanni Muncipinto; Aravind Subramanian; Clary Clish; Kiran Musunuru; Jeremy R. Duvall; Michael Foley; Jose R. Perez; Michelle A. J. Palmer

doi:10.1371/journal.pone.0120295

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Open Access

Peer-reviewed

Research Article

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Marek M. Nagiec ,

* E-mail: marek@broadinstitute.org (MMN); cellnetworx@gmail.com (MAJP)

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Adam P. Skepner,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Joseph Negri,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Michelle Eichhorn,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Nicolas Kuperwasser,

Affiliation Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Eamon Comer,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Giovanni Muncipinto,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Aravind Subramanian,

Affiliation Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Clary Clish,

Affiliation Metabolite Profiling Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Kiran Musunuru,

Affiliation Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Jeremy R. Duvall,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Michael Foley,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Jose R. Perez,

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Michelle A. J. Palmer

* E-mail: marek@broadinstitute.org (MMN); cellnetworx@gmail.com (MAJP)

Affiliation Therapeutics Platform, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Marek M. Nagiec,
Adam P. Skepner,
Joseph Negri,
Michelle Eichhorn,
Nicolas Kuperwasser,
Eamon Comer,
Giovanni Muncipinto,
Aravind Subramanian,
Clary Clish,
Kiran Musunuru

Published: March 26, 2015
https://doi.org/10.1371/journal.pone.0120295

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Cholesterol
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Gene expression
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Lipid metabolism
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Lipoprotein metabolism
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Lipoprotein secretion
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