The Transcription Factor C-Myc Suppresses MiR-23b and MiR-27b Transcription during Fetal Distress and Increases the Sensitivity of Neurons to Hypoxia-Induced Apoptosis

Qun Chen; Fan Zhang; Yanbo Wang; Zhengya Liu; Anyang Sun; Ke Zen; Chen-yu Zhang; Qipeng Zhang

doi:10.1371/journal.pone.0120217

Loading metrics

Open Access

Peer-reviewed

Research Article

The Transcription Factor C-Myc Suppresses MiR-23b and MiR-27b Transcription during Fetal Distress and Increases the Sensitivity of Neurons to Hypoxia-Induced Apoptosis

Qun Chen,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Fan Zhang,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Yanbo Wang,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Zhengya Liu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Anyang Sun ,

* E-mail: qpzhang@nju.edu.cn (QPZ); cyzhang@nju.edu.cn (CYZ); kzen@nju.edu.cn (KZ); anyangsun@hotmail.com (AYS)

Affiliation Laboratory of Neurodegenerative Diseases and Repair, Yancheng Institute of Health Sciences, Yancheng, China
⨯
Ke Zen ,

* E-mail: qpzhang@nju.edu.cn (QPZ); cyzhang@nju.edu.cn (CYZ); kzen@nju.edu.cn (KZ); anyangsun@hotmail.com (AYS)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Chen-yu Zhang ,

* E-mail: qpzhang@nju.edu.cn (QPZ); cyzhang@nju.edu.cn (CYZ); kzen@nju.edu.cn (KZ); anyangsun@hotmail.com (AYS)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Qipeng Zhang

* E-mail: qpzhang@nju.edu.cn (QPZ); cyzhang@nju.edu.cn (CYZ); kzen@nju.edu.cn (KZ); anyangsun@hotmail.com (AYS)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯

The Transcription Factor C-Myc Suppresses MiR-23b and MiR-27b Transcription during Fetal Distress and Increases the Sensitivity of Neurons to Hypoxia-Induced Apoptosis

Qun Chen,
Fan Zhang,
Yanbo Wang,
Zhengya Liu,
Anyang Sun,
Ke Zen,
Chen-yu Zhang,
Qipeng Zhang

Published: March 17, 2015
https://doi.org/10.1371/journal.pone.0120217

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Medical hypoxia
Is the Subject Area "Medical hypoxia" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
Neuronal tuning
Is the Subject Area "Neuronal tuning" applicable to this article?

Thanks for your feedback.