Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

Ivana Bulatovic; Cristian Ibarra; Cecilia Österholm; Heng Wang; Antonio Beltrán-Rodríguez; Manuel Varas-Godoy; Agneta Månsson-Broberg; Per Uhlén; András Simon; Karl-Henrik Grinnemo

doi:10.1371/journal.pone.0120176

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Open Access

Peer-reviewed

Research Article

Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

Ivana Bulatovic ,

Contributed equally to this work with: Ivana Bulatovic, Cristian Ibarra

Affiliation Division of Cardiothoracic Surgery and Anesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Cristian Ibarra ,

Contributed equally to this work with: Ivana Bulatovic, Cristian Ibarra

Current address: Cardiovascular and Metabolic Diseases iMed, AstraZeneca R&D, Mölndal, Sweden.

Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Cecilia Österholm,

Affiliation Division of Cardiothoracic Surgery and Anesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Heng Wang,

Affiliation Department of Cellular and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Antonio Beltrán-Rodríguez,

Affiliation Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
⨯
Manuel Varas-Godoy,

Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Agneta Månsson-Broberg,

Affiliation Division of Cardiology, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯
Per Uhlén,

Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
András Simon ,

¶‡ These authors also contributed equally to this work.

Affiliation Department of Cellular and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Karl-Henrik Grinnemo

* E-mail: karl-henrik.grinnemo@karolinska.se

¶‡ These authors also contributed equally to this work.

Affiliation Division of Cardiothoracic Surgery and Anesthesiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
⨯

Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

Ivana Bulatovic,
Cristian Ibarra,
Cecilia Österholm,
Heng Wang,
Antonio Beltrán-Rodríguez,
Manuel Varas-Godoy,
Agneta Månsson-Broberg,
Per Uhlén,
András Simon,
Karl-Henrik Grinnemo

Published: March 12, 2015
https://doi.org/10.1371/journal.pone.0120176

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Cell differentiation
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Cardiomyocytes
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Apoptosis
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Stem cells
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Muscle differentiation
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Gene expression
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Cell staining
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Embryonic stem cells
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