Evaluation of Arecoline Hydrobromide Toxicity after a 14-Day Repeated Oral Administration in Wistar Rats

Xiaojuan Wei; Jiyu Zhang; Jianrong Niu; Xuzheng Zhou; Jianyong Li; Bing Li

doi:10.1371/journal.pone.0120165

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Open Access

Peer-reviewed

Research Article

Evaluation of Arecoline Hydrobromide Toxicity after a 14-Day Repeated Oral Administration in Wistar Rats

Xiaojuan Wei ,

Contributed equally to this work with: Xiaojuan Wei, Jiyu Zhang

* E-mail: wxjsqss@163.com

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

¶‡ These authors are co-first authors to this work.

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯
Jiyu Zhang ,

Contributed equally to this work with: Xiaojuan Wei, Jiyu Zhang

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

¶‡ These authors are co-first authors to this work.

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯
Jianrong Niu,

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯
Xuzheng Zhou,

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯
Jianyong Li,

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯
Bing Li

Current address: Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou City, Gansu Province,730050, PR China

Affiliations Key Laboratory of New Animal Drug Project of Gansu Province, Gansu Province, China, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Gansu Province, China, Lanzhou Institute of Husbandryand Pharmaceutical Sciences of CAAS, Jiangouyan, Qilihe District, Lanzhou 730050, PR China
⨯

Evaluation of Arecoline Hydrobromide Toxicity after a 14-Day Repeated Oral Administration in Wistar Rats

Xiaojuan Wei,
Jiyu Zhang,
Jianrong Niu,
Xuzheng Zhou,
Jianyong Li,
Bing Li

Published: April 16, 2015
https://doi.org/10.1371/journal.pone.0120165

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