Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells

Daniela Pezzolla; Javier López-Beas; Christian C. Lachaud; Alejandro Domínguez-Rodríguez; Tarik Smani; Abdelkrim Hmadcha; Bernat Soria

doi:10.1371/journal.pone.0119904

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Peer-reviewed

Research Article

Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells

Daniela Pezzolla,

Affiliations Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER)—Fundación Progreso y Salud (FPS), Sevilla, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain
⨯
Javier López-Beas,

Affiliations Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER)—Fundación Progreso y Salud (FPS), Sevilla, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain
⨯
Christian C. Lachaud,

Affiliation Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER)—Fundación Progreso y Salud (FPS), Sevilla, Spain
⨯
Alejandro Domínguez-Rodríguez,

Affiliation Cardiovascular Pathophysiology, Institute of Biomedicine of Seville (IBIS), Sevilla, Spain
⨯
Tarik Smani,

Affiliation Cardiovascular Pathophysiology, Institute of Biomedicine of Seville (IBIS), Sevilla, Spain
⨯
Abdelkrim Hmadcha ,

* E-mail: karim.hmadcha@cabimer.es

¶‡ These authors are joint senior authors on this work.

Affiliations Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER)—Fundación Progreso y Salud (FPS), Sevilla, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain
⨯
Bernat Soria

¶‡ These authors are joint senior authors on this work.

Affiliations Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER)—Fundación Progreso y Salud (FPS), Sevilla, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain
⨯

Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells

Daniela Pezzolla,
Javier López-Beas,
Christian C. Lachaud,
Alejandro Domínguez-Rodríguez,
Tarik Smani,
Abdelkrim Hmadcha,
Bernat Soria

Published: March 16, 2015
https://doi.org/10.1371/journal.pone.0119904

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