Rational Manipulation of mRNA Folding Free Energy Allows Rheostat Control of Pneumolysin Production by Streptococcus pneumoniae

• Fábio E. Amaral,

  Affiliations Department of Pediatrics, Columbia University, New York, NY United States of America, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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• Dane Parker,

  Affiliation Department of Pediatrics, Columbia University, New York, NY United States of America

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• Tara M. Randis,

  Affiliation Department of Pediatrics, Columbia University, New York, NY United States of America

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• Ritwij Kulkarni,

  Affiliation Department of Pediatrics, Columbia University, New York, NY United States of America

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• Alice S. Prince,

  Affiliations Department of Pediatrics, Columbia University, New York, NY United States of America, Department of Pharmacology, Columbia University, New York, NY, United States of America

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• Mimi M. Shirasu-Hiza,

  Affiliation Department of Genetics & Development, Columbia University, New York, NY, United States of America

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• Adam J. Ratner

  * E-mail: ar127@columbia.edu

  Affiliation Department of Pediatrics, Columbia University, New York, NY United States of America

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