HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

Jayasri Nanduri; Damodara Reddy Vaddi; Shakil A. Khan; Ning Wang; Vladislav Makarenko; Gregg L. Semenza; Nanduri R. Prabhakar

doi:10.1371/journal.pone.0119762

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Peer-reviewed

Research Article

HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

Jayasri Nanduri ,

* E-mail: jnanduri@uchicago.edu

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
⨯
Damodara Reddy Vaddi,

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
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Shakil A. Khan,

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
⨯
Ning Wang,

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
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Vladislav Makarenko,

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
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Gregg L. Semenza,

Affiliation Vascular Program, Institute for Cell Engineering; Department of Pediatrics, Medicine, Oncology, Radiation Oncology and Biological Chemistry; and Mckusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Nanduri R. Prabhakar

Affiliation Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
⨯

HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

Jayasri Nanduri,
Damodara Reddy Vaddi,
Shakil A. Khan,
Ning Wang,
Vladislav Makarenko,
Gregg L. Semenza,
Nanduri R. Prabhakar

Published: March 9, 2015
https://doi.org/10.1371/journal.pone.0119762

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