Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

• Jennifer E. Huffman,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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• Eva Albrecht,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

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• Alexander Teumer,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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• Massimo Mangino,

  Affiliation King's College London, St. Thomas' Hospital Campus, London, United Kingdom

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• Karen Kapur,

  Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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• Toby Johnson,

  Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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• Zoltán Kutalik,

  Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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• Nicola Pirastu,

  Affiliations Institute for Maternal and Child Health—Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy, University of Trieste, Trieste, Italy

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• Giorgio Pistis,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

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• Lorna M. Lopez,

  Affiliations Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

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• Toomas Haller,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Perttu Salo,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland

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• Anuj Goel,

  Affiliation Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Man Li,

  Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America

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• Toshiko Tanaka,

  Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America

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• Abbas Dehghan,

  Affiliations Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Daniela Ruggiero,

  Affiliation Institute of Genetics and Biophysics "A. Buzzati-Traverso"—Consiglio Nazionale delle Ricerche (CNR), Naples, Italy

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• Giovanni Malerba,

  Affiliation Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy

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• Albert V. Smith,

  Affiliations Icelandic Heart Association Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Ilja M. Nolte,

  Affiliation Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Laura Portas,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

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• Amanda Phipps-Green,

  Affiliation Department of Biochemistry, University of Otago, Dunedin, New Zealand

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• Lora Boteva,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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• Pau Navarro,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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• Asa Johansson,

  Affiliations Uppsala Clinical Research Center, Uppsala University Hospital, Upsalla, Sweden, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden

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• Andrew A. Hicks,

  Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany

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• Ozren Polasek,

  Affiliation Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia

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• Tõnu Esko,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Broad Institute, Cambridge, MA, United States of America, Children’s Hospital Boston, Boston, MA, United States of America

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• John F. Peden,

  Affiliation Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Sarah E. Harris,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom, Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

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• Federico Murgia,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

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• Sarah H. Wild,

  Affiliation Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Albert Tenesa,

  Affiliations Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom, Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom

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• Adrienne Tin,

  Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America

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• Evelin Mihailov,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Anne Grotevendt,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

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• Gauti K. Gislason,

  Affiliation Icelandic Heart Association Research Institute, Kopavogur, Iceland

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• Josef Coresh,

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America

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• Pio D'Adamo,

  Affiliations Institute for Maternal and Child Health—Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy, University of Trieste, Trieste, Italy

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• Sheila Ulivi,

  Affiliation Institute for Maternal and Child Health—Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy

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• Peter Vollenweider,

  Affiliation Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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• Gerard Waeber,

  Affiliation Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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• Susan Campbell,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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• Ivana Kolcic,

  Affiliation Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia

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• Krista Fisher,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Margus Viigimaa,

  Affiliations Tallinn University of Technology, Department of Biomedical Engineering, Chair of Medical Physics, Tallinn, Estonia, Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia

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• Jeffrey E. Metter,

  Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America

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• Corrado Masciullo,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

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• Elisabetta Trabetti,

  Affiliation Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy

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• Cristina Bombieri,

  Affiliation Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy

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• Rossella Sorice,

  Affiliation Institute of Genetics and Biophysics "A. Buzzati-Traverso"—Consiglio Nazionale delle Ricerche (CNR), Naples, Italy

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• Angela Döring,

  Affiliations Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

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• Eva Reischl,

  Affiliations Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

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• Konstantin Strauch,

  Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany

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• Albert Hofman,

  Affiliations Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Andre G. Uitterlinden,

  Affiliations Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Melanie Waldenberger,

  Affiliations Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

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• H-Erich Wichmann,

  Affiliations Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany, Klinikum Grosshadern, Munich, Germany

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• Gail Davies,

  Affiliations Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

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• Alan J. Gow,

  Affiliations Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

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• Nicola Dalbeth,

  Affiliation Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand

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• Lisa Stamp,

  Affiliation Department of Medicine, University of Otago, Christchurch, New Zealand

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• Johannes H. Smit,

  Affiliation Department of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands

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• Mirna Kirin,

  Affiliation Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Ramaiah Nagaraja,

  Affiliation Laboratory of Genetics, National Institute on Aging (NIA), Baltimore, MD, United States of America

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• Matthias Nauck,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

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• Claudia Schurmann,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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• Kathrin Budde,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

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• Susan M. Farrington,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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• Evropi Theodoratou,

  Affiliation Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Antti Jula,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland

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• Veikko Salomaa,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland

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• Cinzia Sala,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

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• Christian Hengstenberg,

  Affiliation University Hospital Regensburg, Regensburg, Germany

  ⨯
• Michel Burnier,

  Affiliation Department of Medicine, Nephrology Division, Lausanne University Hospital, Lausanne, Switzerland

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• Reedik Mägi,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Norman Klopp,

  Affiliation Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany

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• Stefan Kloiber,

  Affiliation Max Planck Institute of Psychiatry, Munich, Germany

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• Sabine Schipf,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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• Samuli Ripatti,

  Affiliations Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland, Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland

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• Stefano Cabras,

  Affiliations Department of Mathematics and Informatics, Università di Cagliari, Cagliari, Italy, Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain

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• Nicole Soranzo,

  Affiliation Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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• Georg Homuth,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

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• Teresa Nutile,

  Affiliation Institute of Genetics and Biophysics "A. Buzzati-Traverso"—Consiglio Nazionale delle Ricerche (CNR), Naples, Italy

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• Patricia B. Munroe,

  Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

  ⨯
• Nicholas Hastie,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Harry Campbell,

  Affiliation Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

  ⨯
• Igor Rudan,

  Affiliations Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia, Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

  ⨯
• Claudia Cabrera,

  Affiliation Queen Mary, University of London, London, United Kingdom

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• Chris Haley,

  Affiliations Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom, Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Oscar H. Franco,

  Affiliations Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

  ⨯
• Tony R. Merriman,

  Affiliation Department of Biochemistry, University of Otago, Dunedin, New Zealand

  ⨯
• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Mario Pirastu,

  Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

  ⨯
• Brenda W. Penninx,

  Affiliations Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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• Harold Snieder,

  Affiliation Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

  ⨯
• Andres Metspalu,

  Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

  ⨯
• Marina Ciullo,

  Affiliation Institute of Genetics and Biophysics "A. Buzzati-Traverso"—Consiglio Nazionale delle Ricerche (CNR), Naples, Italy

  ⨯
• Peter P. Pramstaller,

  Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany

  ⨯
• Cornelia M. van Duijn,

  Affiliation Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands

  ⨯
• Luigi Ferrucci,

  Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America

  ⨯
• Giovanni Gambaro,

  Affiliation Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy

  ⨯
• Ian J. Deary,

  Affiliations Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Malcolm G. Dunlop,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• James F. Wilson,

  Affiliation Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom

  ⨯
• Paolo Gasparini,

  Affiliations Institute for Maternal and Child Health—Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy, University of Trieste, Trieste, Italy

  ⨯
• Ulf Gyllensten,

  Affiliation Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden

  ⨯
• Tim D. Spector,

  Affiliation King's College London, St. Thomas' Hospital Campus, London, United Kingdom

  ⨯
• Alan F. Wright,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Caroline Hayward,

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Hugh Watkins,

  Affiliation on behalf of PROCARDIS; Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Markus Perola,

  Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland, University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland

  ⨯
• Murielle Bochud,

  Affiliation University Institute of Social and Preventive Medicine, Lausanne, Switzerland

  ⨯
• W. H. Linda Kao,

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America

  ⨯
• Mark Caulfield,

  Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

  ⨯
• Daniela Toniolo,

  Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Christian Gieger,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

  ⨯
• Anna Köttgen,

  Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America, Renal Division, Freiburg University Hospital, Freiburg, Germany

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•  [ ... ],
• Veronique Vitart

  * E-mail: veronique.vitart@igmm.ed.ac.uk

  Affiliation Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom

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