Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Yongwei Zheng; Tamara Adams; Huiying Zhi; Mei Yu; Renren Wen; Peter J. Newman; Demin Wang; Debra K. Newman

doi:10.1371/journal.pone.0119739

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Peer-reviewed

Research Article

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Yongwei Zheng,

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, Jiangsu, People’s Republic of China
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Tamara Adams,

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America
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Huiying Zhi,

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America
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Mei Yu,

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America
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Renren Wen,

Affiliation Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America
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Peter J. Newman,

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Demin Wang,

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Debra K. Newman

* E-mail: Debra.Newman@bcw.edu

Affiliations Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Yongwei Zheng,
Tamara Adams,
Huiying Zhi,
Mei Yu,
Renren Wen,
Peter J. Newman,
Demin Wang,
Debra K. Newman

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0119739

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