Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

Wensheng Xie; Marie Pariollaud; William E. Wixted; Nilesh Chitnis; James Fornwald; Maggie Truong; Christina Pao; Yan Liu; Robert S. Ames; James Callahan; Roberto Solari; Yolanda Sanchez; Alan Diehl; Hu Li

doi:10.1371/journal.pone.0119738

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Open Access

Peer-reviewed

Research Article

Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

Wensheng Xie,

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Marie Pariollaud,

Affiliation Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
William E. Wixted,

Affiliation Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Nilesh Chitnis,

Affiliation Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
James Fornwald,

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Maggie Truong,

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Christina Pao,

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Yan Liu,

Affiliation Department of Sample Management Technologies, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Robert S. Ames,

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
James Callahan,

Affiliation Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Roberto Solari,

Affiliation Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom
⨯
Yolanda Sanchez,

Affiliation Stress & Repair Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Alan Diehl,

Affiliation Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Hu Li

* E-mail: hu.li@gsk.com

Affiliation Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯

Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

Wensheng Xie,
Marie Pariollaud,
William E. Wixted,
Nilesh Chitnis,
James Fornwald,
Maggie Truong,
Christina Pao,
Yan Liu,
Robert S. Ames,
James Callahan

Published: March 17, 2015
https://doi.org/10.1371/journal.pone.0119738

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