Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

Masataka Ikeda; Tomomi Ide; Takeo Fujino; Shinobu Arai; Keita Saku; Takamori Kakino; Henna Tyynismaa; Toshihide Yamasaki; Ken-ichi Yamada; Dongchon Kang; Anu Suomalainen; Kenji Sunagawa

doi:10.1371/journal.pone.0119687

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Open Access

Peer-reviewed

Research Article

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

Masataka Ikeda,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Tomomi Ide ,

* E-mail: tomomi_i@cardiol.med.kyushu-u.ac.jp

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takeo Fujino,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Shinobu Arai,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Keita Saku,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takamori Kakino,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Henna Tyynismaa,

Affiliation Research Programs Unit, Molecular Neurology, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland
⨯
Toshihide Yamasaki,

Affiliation Department of Biofunctional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
⨯
Ken-ichi Yamada,

Affiliation Department of Biofunctional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
⨯
Dongchon Kang,

Affiliation Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Anu Suomalainen,

Affiliation Research Programs Unit, Molecular Neurology, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland
⨯
Kenji Sunagawa

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

Masataka Ikeda,
Tomomi Ide,
Takeo Fujino,
Shinobu Arai,
Keita Saku,
Takamori Kakino,
Henna Tyynismaa,
Toshihide Yamasaki,
Ken-ichi Yamada,
Dongchon Kang

Published: March 30, 2015
https://doi.org/10.1371/journal.pone.0119687

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