Translational Arrest Due to Cytoplasmic Redox Stress Delays Adaptation to Growth on Methanol and Heterologous Protein Expression in a Typical Fed-Batch Culture of Pichia pastoris

• Bryn Edwards-Jones,

  Affiliation Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, United Kingdom

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• Rochelle Aw,

  Affiliation Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, United Kingdom

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• Geraint R. Barton,

  Affiliation Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, United Kingdom

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• Gregory D. Tredwell,

  Affiliation Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom

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• Jacob G. Bundy,

  Affiliation Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom

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• David J. Leak

  * E-mail: d.j.leak@bath.ac.uk

  Affiliations Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, United Kingdom, Department of Biology & Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom

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