Priming with a Simplified Intradermal HIV-1 DNA Vaccine Regimen followed by Boosting with Recombinant HIV-1 MVA Vaccine Is Safe and Immunogenic: A Phase IIa Randomized Clinical Trial

• Patricia. J. Munseri ,

  Contributed equally to this work with: Patricia. J. Munseri, Arne Kroidl

  * E-mail: pmunseri@yahoo.com

  Affiliations Department of Internal Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania, Venhalsan, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden

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• Arne Kroidl ,

  Contributed equally to this work with: Patricia. J. Munseri, Arne Kroidl

  Affiliations National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany

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• Charlotta Nilsson,

  Affiliations The Public Health Agency of Sweden, Solna, Sweden, Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden

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• Agricola Joachim,

  Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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• Christof Geldmacher,

  Affiliations Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany

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• Philipp Mann,

  Affiliations National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany

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• Candida Moshiro,

  Affiliation Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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• Said Aboud,

  Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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• Eligius Lyamuya,

  Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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• Leonard Maboko,

  Affiliation National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania

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• Marco Missanga,

  Affiliation National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania

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• Bahati Kaluwa,

  Affiliation National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania

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• Sayoki Mfinanga,

  Affiliation National Institute for Medical Research—Muhimbili Medical Research Centre, Dar es Salaam, Tanzania

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• Lilly Podola,

  Affiliations National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany

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• Asli Bauer,

  Affiliations National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany

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• Karina Godoy-Ramirez,

  Affiliation The Public Health Agency of Sweden, Solna, Sweden

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• Mary Marovich,

  Affiliation Walter Reed Army Institute of Research (WRAIR), Rockville, MD, United States of America and The Henry M. Jackson Foundation, Rockville, MD, United States of America

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• Bernard Moss,

  Affiliation Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, United States of America

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• Michael Hoelscher,

  Affiliations National Institute for Medical Research—Mbeya Medical Research Center, Mbeya, Tanzania, Department of Infectious Diseases and Tropical Medicine, Klinikum of the University of Munich, Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany

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• Frances Gotch,

  Affiliation Imperial College, London, United Kingdom

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• Wolfgang Stöhr,

  Affiliation Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom

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• Richard Stout,

  Affiliation Bioject Medical Technologies, 7180 SW Sandburg St, Tigard, Oregon, United States of America

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• Sheena McCormack,

  Affiliation Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom

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• Britta Wahren,

  Affiliation Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden

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• Fred Mhalu,

  Affiliation Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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• Merlin L. Robb,

  Affiliation Walter Reed Army Institute of Research (WRAIR), Rockville, MD, United States of America and The Henry M. Jackson Foundation, Rockville, MD, United States of America

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• Gunnel Biberfeld,

  Affiliations The Public Health Agency of Sweden, Solna, Sweden, Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden

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• Eric Sandström,

  Affiliation Venhalsan, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden

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•  [ ... ],
• Muhammad Bakari

  Affiliation Department of Internal Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania

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