Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

Julie L. Boerner; Nicole Nechiporchik; Kelly L. Mueller; Lisa Polin; Lance Heilbrun; Scott A. Boerner; Gina L. Zoratti; Karri Stark; Patricia M. LoRusso; Angelika Burger

doi:10.1371/journal.pone.0119614

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Open Access

Peer-reviewed

Research Article

Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

Julie L. Boerner ,

* E-mail: boernerj@karmanos.org

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Nicole Nechiporchik,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Kelly L. Mueller,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Lisa Polin,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Lance Heilbrun,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Scott A. Boerner,

Affiliations Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America, Department of Oncology, Yale University, New Haven, Connecticut, United States of America
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Gina L. Zoratti,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Karri Stark,

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
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Patricia M. LoRusso,

Affiliations Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America, Department of Oncology, Yale University, New Haven, Connecticut, United States of America
⨯
Angelika Burger

Affiliation Department of Oncology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯

Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

Julie L. Boerner,
Nicole Nechiporchik,
Kelly L. Mueller,
Lisa Polin,
Lance Heilbrun,
Scott A. Boerner,
Gina L. Zoratti,
Karri Stark,
Patricia M. LoRusso,
Angelika Burger

Published: March 16, 2015
https://doi.org/10.1371/journal.pone.0119614

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Cancer treatment
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Cancers and neoplasms
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Breast cancer
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DNA damage
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Protein expression
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DNA repair
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