Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Juan Pablo Rigalli; Nadia Ciriaci; Agostina Arias; María Paula Ceballos; Silvina Stella Maris Villanueva; Marcelo Gabriel Luquita; Aldo Domingo Mottino; Carolina Inés Ghanem; Viviana Alicia Catania; María Laura Ruiz

doi:10.1371/journal.pone.0119502

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Open Access

Peer-reviewed

Research Article

Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Juan Pablo Rigalli,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Nadia Ciriaci,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Agostina Arias,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
María Paula Ceballos,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Silvina Stella Maris Villanueva,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Marcelo Gabriel Luquita,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Aldo Domingo Mottino,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
Carolina Inés Ghanem,

Affiliation Institute of Pharmacological Investigations (ININFA-CONICET), Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
⨯
Viviana Alicia Catania,

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯
María Laura Ruiz

* E-mail: ruiz@ifise-conicet.gov.ar

Affiliation Institute of Experimental Physiology (IFISE-CONICET), Faculty of Biochemical and Pharmaceutical Science, Rosario National University, Rosario, Argentina
⨯

Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Juan Pablo Rigalli,
Nadia Ciriaci,
Agostina Arias,
María Paula Ceballos,
Silvina Stella Maris Villanueva,
Marcelo Gabriel Luquita,
Aldo Domingo Mottino,
Carolina Inés Ghanem,
Viviana Alicia Catania,
María Laura Ruiz

Published: March 17, 2015
https://doi.org/10.1371/journal.pone.0119502

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Hepatocellular carcinoma
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Cytotoxicity
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Messenger RNA
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Protein expression
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Protein translation
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Cell membranes
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MicroRNAs
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