Involvement of Cytochrome P450 1A1 and Glutathione S-Transferase P1 Polymorphisms and Promoter Hypermethylation in the Progression of Anti-Tuberculosis Drug-Induced Liver Injury: A Case–Control Study

Lei He; Li Gao; Zhe Shi; Yuhong Li; Lingyan Zhu; Shiming Li; Peng Zhang; Guoying Zheng; Qi Ren; Yun Li; Bo Hu; Fumin Feng

doi:10.1371/journal.pone.0119481

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Open Access

Peer-reviewed

Research Article

Involvement of Cytochrome P450 1A1 and Glutathione S-Transferase P1 Polymorphisms and Promoter Hypermethylation in the Progression of Anti-Tuberculosis Drug-Induced Liver Injury: A Case–Control Study

Lei He,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Li Gao,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Zhe Shi,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Yuhong Li,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Lingyan Zhu,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Shiming Li,

Affiliation Department of Clinical Laboratories, Tangshan Tuberculosis Hospital, Tangshan 063000, China
⨯
Peng Zhang,

Affiliation Department of Clinical Laboratories, Tangshan Tuberculosis Hospital, Tangshan 063000, China
⨯
Guoying Zheng,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Qi Ren,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Yun Li,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Bo Hu,

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯
Fumin Feng

* E-mail: fm_feng@sina.com

Affiliation Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan 063000, China
⨯

Involvement of Cytochrome P450 1A1 and Glutathione S-Transferase P1 Polymorphisms and Promoter Hypermethylation in the Progression of Anti-Tuberculosis Drug-Induced Liver Injury: A Case–Control Study

Lei He,
Li Gao,
Zhe Shi,
Yuhong Li,
Lingyan Zhu,
Shiming Li,
Peng Zhang,
Guoying Zheng,
Qi Ren,
Yun Li

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0119481

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DNA methylation
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Variant genotypes
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