Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability

Sanki Asakawa; Yu Kishimoto; Takayuki Takano; Kiyuki Okita; Shiho Takakuwa; Taiki Sato; Masahiro Hiratsuka; Osamu Takeuchi; Noriyasu Hirasawa

doi:10.1371/journal.pone.0119428

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Peer-reviewed

Research Article

Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability

Sanki Asakawa,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Yu Kishimoto,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Takayuki Takano,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Kiyuki Okita,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Shiho Takakuwa,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Taiki Sato,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Masahiro Hiratsuka,

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯
Osamu Takeuchi,

Affiliation Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Shogoin Kawara-cho, Sakyo-ku, Kyoto, Japan
⨯
Noriyasu Hirasawa

* E-mail: hirasawa@m.tohoku.ac.jp

Affiliation Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
⨯

Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability

Sanki Asakawa,
Yu Kishimoto,
Takayuki Takano,
Kiyuki Okita,
Shiho Takakuwa,
Taiki Sato,
Masahiro Hiratsuka,
Osamu Takeuchi,
Noriyasu Hirasawa

Published: March 5, 2015
https://doi.org/10.1371/journal.pone.0119428

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