Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

Divakara S. S. M. Uppu; Goutham B. Manjunath; Venkateswarlu Yarlagadda; Jyothi E. Kaviyil; Raju Ravikumar; Krishnamoorthy Paramanandham; Bibek R. Shome; Jayanta Haldar

doi:10.1371/journal.pone.0119422

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Open Access

Peer-reviewed

Research Article

Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

Divakara S. S. M. Uppu,

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India
⨯
Goutham B. Manjunath,

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India
⨯
Venkateswarlu Yarlagadda,

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India
⨯
Jyothi E. Kaviyil,

Affiliation Department of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, Bangalore, 560029, India
⨯
Raju Ravikumar,

Affiliation Department of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, Bangalore, 560029, India
⨯
Krishnamoorthy Paramanandham,

Affiliation National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Hebbal, Bengaluru, 560024, Karnataka, India
⨯
Bibek R. Shome,

Affiliation National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Hebbal, Bengaluru, 560024, Karnataka, India
⨯
Jayanta Haldar

* E-mail: jayanta@jncasr.ac.in

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, 560064, India
⨯

Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

Divakara S. S. M. Uppu,
Goutham B. Manjunath,
Venkateswarlu Yarlagadda,
Jyothi E. Kaviyil,
Raju Ravikumar,
Krishnamoorthy Paramanandham,
Bibek R. Shome,
Jayanta Haldar

Published: March 19, 2015
https://doi.org/10.1371/journal.pone.0119422

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