Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Manabu Kawada; Hiroyuki Inoue; Shun-ichi Ohba; Junjiro Yoshida; Tohru Masuda; Manabu Yamasaki; Ihomi Usami; Shuichi Sakamoto; Hikaru Abe; Takumi Watanabe; Takao Yamori; Masakatsu Shibasaki; Akio Nomoto

doi:10.1371/journal.pone.0119415

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Open Access

Peer-reviewed

Research Article

Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Manabu Kawada ,

* E-mail: kawadam@bikaken.or.jp

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Hiroyuki Inoue,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Shun-ichi Ohba,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Junjiro Yoshida,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Tohru Masuda,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Manabu Yamasaki,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Tokyo, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan
⨯
Ihomi Usami,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Shuichi Sakamoto,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯
Hikaru Abe,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Tokyo, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan
⨯
Takumi Watanabe,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Tokyo, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan
⨯
Takao Yamori,

Affiliation The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
⨯
Masakatsu Shibasaki,

Affiliation Institute of Microbial Chemistry (BIKAKEN), Tokyo, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan
⨯
Akio Nomoto

Affiliation Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan
⨯

Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Manabu Kawada,
Hiroyuki Inoue,
Shun-ichi Ohba,
Junjiro Yoshida,
Tohru Masuda,
Manabu Yamasaki,
Ihomi Usami,
Shuichi Sakamoto,
Hikaru Abe,
Takumi Watanabe

Published: March 18, 2015
https://doi.org/10.1371/journal.pone.0119415

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