Expression of Dominant-Negative Thyroid Hormone Receptor Alpha1 in Leydig and Sertoli Cells Demonstrates No Additional Defect Compared with Expression in Sertoli Cells Only

Betty Fumel; Pascal Froment; Martin Holzenberger; Gabriel Livera; Philippe Monget; Sophie Fouchécourt

doi:10.1371/journal.pone.0119392

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Research Article

Expression of Dominant-Negative Thyroid Hormone Receptor Alpha1 in Leydig and Sertoli Cells Demonstrates No Additional Defect Compared with Expression in Sertoli Cells Only

Betty Fumel,

Affiliations INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, CNRS, UMR7247 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, Université François Rabelais de Tours, F-37041, Tours, France, IFCE, F-37380, Nouzilly, France
⨯
Pascal Froment,

Affiliations INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, CNRS, UMR7247 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, Université François Rabelais de Tours, F-37041, Tours, France, IFCE, F-37380, Nouzilly, France
⨯
Martin Holzenberger,

Affiliation INSERM and Sorbonne Universités—UPMC, UMRS 938, Hôpital Saint-Antoine, 75012, Paris, France
⨯
Gabriel Livera,

Affiliation Laboratoire de Développement des Gonades, INSERM U967, CEA/DSV/iRCM/SCSR/LDG, Univ Paris Diderot, Sorbonne Paris Cité, Univ Paris Sud, F-92265, Fontenay-Aux-Roses, France
⨯
Philippe Monget,

Affiliations INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, CNRS, UMR7247 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, Université François Rabelais de Tours, F-37041, Tours, France, IFCE, F-37380, Nouzilly, France
⨯
Sophie Fouchécourt

* E-mail: sophie.fouchecourt@tours.inra.fr

Affiliations INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, CNRS, UMR7247 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France, Université François Rabelais de Tours, F-37041, Tours, France, IFCE, F-37380, Nouzilly, France
⨯

Expression of Dominant-Negative Thyroid Hormone Receptor Alpha1 in Leydig and Sertoli Cells Demonstrates No Additional Defect Compared with Expression in Sertoli Cells Only

Betty Fumel,
Pascal Froment,
Martin Holzenberger,
Gabriel Livera,
Philippe Monget,
Sophie Fouchécourt

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0119392

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