Comparative Proteome Analysis of Brown Adipose Tissue in Obese C57BL/6J Mice Using iTRAQ-Coupled 2D LC-MS/MS

Juan Li; Wei-Gang Zhao; Zhu-Fang Shen; Tao Yuan; Shuai-Nan Liu; Quan Liu; Yong Fu; Wei Sun

doi:10.1371/journal.pone.0119350

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Open Access

Peer-reviewed

Research Article

Comparative Proteome Analysis of Brown Adipose Tissue in Obese C57BL/6J Mice Using iTRAQ-Coupled 2D LC-MS/MS

Juan Li,

Affiliation Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Wei-Gang Zhao ,

* E-mail: xiehezhaoweigang@163.com (WGZ); sunwei1018@sina.com (WS).

Affiliation Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Zhu-Fang Shen,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing, China
⨯
Tao Yuan,

Affiliation Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Shuai-Nan Liu,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing, China
⨯
Quan Liu,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing, China
⨯
Yong Fu,

Affiliation Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Wei Sun

* E-mail: xiehezhaoweigang@163.com (WGZ); sunwei1018@sina.com (WS).

Affiliation Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China
⨯

Comparative Proteome Analysis of Brown Adipose Tissue in Obese C57BL/6J Mice Using iTRAQ-Coupled 2D LC-MS/MS

Juan Li,
Wei-Gang Zhao,
Zhu-Fang Shen,
Tao Yuan,
Shuai-Nan Liu,
Quan Liu,
Yong Fu,
Wei Sun

Published: March 6, 2015
https://doi.org/10.1371/journal.pone.0119350

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Brown adipose tissue
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Obesity
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Mitochondria
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Apoptosis
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Protein expression
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Fatty acids
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Insulin
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