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Open Access

Peer-reviewed

Research Article

SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest

Manuj Tandon,

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Joseph M. Salamoun,

Affiliation Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Evan J. Carder,

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Elisa Farber,

Affiliation Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Shuping Xu,

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Fan Deng,

Affiliation Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Hua Tang,

Affiliation Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, United States of America
⨯
Peter Wipf,

Affiliation Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Q. Jane Wang

* E-mail: qjw1@pitt.edu

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯

SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest

Manuj Tandon,
Joseph M. Salamoun,
Evan J. Carder,
Elisa Farber,
Shuping Xu,
Fan Deng,
Hua Tang,
Peter Wipf,
Q. Jane Wang

x

Published: March 6, 2015
https://doi.org/10.1371/journal.pone.0119346

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Prostate cancer
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Cancer treatment
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Cell proliferation
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In vitro kinase assay
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Cancers and neoplasms
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Cell cycle and cell division
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Small molecules
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Phosphorylation
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