Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

Rajarajan A. Thandavarayan; Vijayasree V. Giridharan; Somasundaram Arumugam; Kenji Suzuki; Kam Ming Ko; Prasanna Krishnamurthy; Kenichi Watanabe; Tetsuya Konishi

doi:10.1371/journal.pone.0119214

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Peer-reviewed

Research Article

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

Rajarajan A. Thandavarayan ,

Contributed equally to this work with: Rajarajan A. Thandavarayan, Vijayasree V. Giridharan

Affiliations Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), Higashijima, Akiha Ku, Niigata, Japan, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Vijayasree V. Giridharan ,

Contributed equally to this work with: Rajarajan A. Thandavarayan, Vijayasree V. Giridharan

Affiliation J.K.K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu, India
⨯
Somasundaram Arumugam,

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), Higashijima, Akiha Ku, Niigata, Japan
⨯
Kenji Suzuki,

Affiliation Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Kam Ming Ko,

Affiliation Section of Biochemistry and Cell Biology, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
⨯
Prasanna Krishnamurthy,

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Kenichi Watanabe,

Affiliation Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), Higashijima, Akiha Ku, Niigata, Japan
⨯
Tetsuya Konishi

* E-mail: konishi@nupals.ac.jp

Affiliation Basic studies on second generation functional foods, NUPALS, NUPALS Liaison R/D promotion devision, Higashi-jima 265-1, Akiha-ku, Niigata, Japan, and Changchun University of Chinese Medicine, Bosuo Road #1035 Jingyue Economic Development District, Changchun, RP China
⨯

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

Rajarajan A. Thandavarayan,
Vijayasree V. Giridharan,
Somasundaram Arumugam,
Kenji Suzuki,
Kam Ming Ko,
Prasanna Krishnamurthy,
Kenichi Watanabe,
Tetsuya Konishi

Published: March 5, 2015
https://doi.org/10.1371/journal.pone.0119214

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