Pregnane X Receptor Knockout Mice Display Aging-Dependent Wearing of Articular Cartilage

• Kotaro Azuma,

  Affiliation Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

  ⨯
• Stephanie C. Casey,

  Affiliation Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697-2300, United States of America

  ⨯
• Tomohiko Urano,

  Affiliations Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, Department of Anti-aging Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

  ⨯
• Kuniko Horie-Inoue,

  Affiliation Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan

  ⨯
• Yasuyoshi Ouchi,

  Affiliations Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan

  ⨯
• Bruce Blumberg,

  Affiliation Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697-2300, United States of America

  ⨯
• Satoshi Inoue

  * E-mail: INOUE-GER@h.u-tokyo.ac.jp

  Affiliations Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, Department of Anti-aging Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan

  ⨯