Bioactivity-Guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)–Epicatechin-3-Gallate and (-)–Epigallocatechin-3-Gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator

• Lei Chen,

  Affiliation School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, P. R. China

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• Bo Yu,

  Affiliation School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, P. R. China

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• Yaofang Zhang,

  Affiliation College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, P. R. China

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• Xin Gao,

  Affiliation School of Medicine, Yanbian University, Yanji, 133002, P. R. China

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• Liang Zhu,

  Affiliation College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, P. R. China

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• Tonghui Ma,

  Affiliations School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, P. R. China, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, P. R. China

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• Hong Yang

  * E-mail: hyanglnnu@gmail.com

  Affiliation School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, P. R. China

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