Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

Yan Weng; Jeffrey R. Chabot; Barbara Bernardo; Qingyun Yan; Yimin Zhu; Martin B. Brenner; Chandra Vage; Alison Logan; Roberto Calle; Saswata Talukdar

doi:10.1371/journal.pone.0119104

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Research Article

Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

Yan Weng ,

Contributed equally to this work with: Yan Weng, Jeffrey R. Chabot

Affiliations Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America, Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
⨯
Jeffrey R. Chabot ,

Contributed equally to this work with: Yan Weng, Jeffrey R. Chabot

Affiliations Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America, Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Barbara Bernardo,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Qingyun Yan,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Yimin Zhu,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Martin B. Brenner,

Current address: Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts, United States of America

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Chandra Vage,

Affiliation Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Alison Logan,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Roberto Calle,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
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Saswata Talukdar

* E-mail: Saswata.Talukdar@pfizer.com

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts, 02139, United States of America
⨯

Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

Yan Weng,
Jeffrey R. Chabot,
Barbara Bernardo,
Qingyun Yan,
Yimin Zhu,
Martin B. Brenner,
Chandra Vage,
Alison Logan,
Roberto Calle,
Saswata Talukdar

Published: March 19, 2015
https://doi.org/10.1371/journal.pone.0119104

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