Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Open Access

Peer-reviewed

Research Article

Shannon D. Shields,

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
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Richard P. Butt,

Affiliation Neusentis UK, Pfizer Global R&D, Cambridge, United Kingdom
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Sulayman D. Dib-Hajj,

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
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Stephen G. Waxman

* E-mail: stephen.waxman@yale.edu

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
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Multiple sclerosis
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Oral administration
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Cerebellum
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Collective animal behavior
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