Microstructural Changes across Different Clinical Milestones of Disease in Amyotrophic Lateral Sclerosis

Francesca Trojsi; Giuseppina Caiazzo; Daniele Corbo; Giovanni Piccirillo; Viviana Cristillo; Cinzia Femiano; Teresa Ferrantino; Mario Cirillo; Maria Rosaria Monsurrò; Fabrizio Esposito; Gioacchino Tedeschi

doi:10.1371/journal.pone.0119045

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Open Access

Peer-reviewed

Research Article

Microstructural Changes across Different Clinical Milestones of Disease in Amyotrophic Lateral Sclerosis

Francesca Trojsi,

Affiliations Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy
⨯
Giuseppina Caiazzo,

Affiliations Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy
⨯
Daniele Corbo,

Affiliation Department of Neuroscience, University of Parma, 43100 Parma, Italy
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Giovanni Piccirillo,

Affiliation Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
⨯
Viviana Cristillo,

Affiliation Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
⨯
Cinzia Femiano,

Affiliation Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
⨯
Teresa Ferrantino,

Affiliation Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
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Mario Cirillo,

Affiliations Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy
⨯
Maria Rosaria Monsurrò,

Affiliations Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy
⨯
Fabrizio Esposito,

Affiliations MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy, Department of Medicine and Surgery, University of Salerno, 84081 Baronissi (Salerno), Italy
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Gioacchino Tedeschi

* E-mail: gioacchino.tedeschi@unina2.it

Affiliations Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy, MRI Research Center SUN-FISM—Second University of Naples, 80138 Naples, Italy
⨯

Microstructural Changes across Different Clinical Milestones of Disease in Amyotrophic Lateral Sclerosis

Francesca Trojsi,
Giuseppina Caiazzo,
Daniele Corbo,
Giovanni Piccirillo,
Viviana Cristillo,
Cinzia Femiano,
Teresa Ferrantino,
Mario Cirillo,
Maria Rosaria Monsurrò,
Fabrizio Esposito

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0119045

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Atrophy
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Voxel-based morphometry
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Amyotrophic lateral sclerosis
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Brainstem
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Diffusion tensor imaging
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Motor system
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