No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

Marta Garcia-Miralles; Janaky Coomaraswamy; Karina Häbig; Martin C. Herzig; Natalja Funk; Frank Gillardon; Martina Maisel; Mathias Jucker; Thomas Gasser; Dagmar Galter; Saskia Biskup

doi:10.1371/journal.pone.0118947

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Peer-reviewed

Research Article

No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

Marta Garcia-Miralles,

Current address: Translational Laboratory in Genetic Medicine (TLGM), Department of Medicine, National University of Singapore and Agency for Science, Technology and Research (A*STAR), 138648 Singapore, Singapore

Affiliation Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Janaky Coomaraswamy,

Current address: Biogen Idec, Department of Neurology Research, Cambridge, MA 02142, USA

Affiliation Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Karina Häbig,

Affiliation Department of Medical Genetics and Applied Genomics, Institute of Human Genetics, University of Tuebingen, 72076 Tuebingen, Germany
⨯
Martin C. Herzig,

Current address: 4056 Basel, Switzerland

Affiliation Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Natalja Funk,

Affiliation Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Frank Gillardon,

Affiliation Boehringer Ingelheim Pharma GmbH & Co. KG, CNS Research, 88397 Biberach an der Riss, Germany
⨯
Martina Maisel,

Current address: Center for Genomics and Transcriptomics (CeGaT), 72076 Tuebingen, Germany

Affiliation Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Mathias Jucker,

Affiliation Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Thomas Gasser,

Affiliation Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯
Dagmar Galter,

Affiliation Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
⨯
Saskia Biskup

* E-mail: saskia.biskup@medizin.uni-tuebingen.de

Affiliation Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and DZNE, German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany
⨯

No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

Marta Garcia-Miralles,
Janaky Coomaraswamy,
Karina Häbig,
Martin C. Herzig,
Natalja Funk,
Frank Gillardon,
Martina Maisel,
Mathias Jucker,
Thomas Gasser,
Dagmar Galter

Published: April 1, 2015
https://doi.org/10.1371/journal.pone.0118947

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