A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

Kyle G. Halvorson; Kelly L. Barton; Kristin Schroeder; Katherine L. Misuraca; Christine Hoeman; Alex Chung; Donna M. Crabtree; Francisco J. Cordero; Raj Singh; Ivan Spasojevic; Noah Berlow; Ranadip Pal; Oren J. Becher

doi:10.1371/journal.pone.0118926

Loading metrics

Open Access

Peer-reviewed

Research Article

A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

Kyle G. Halvorson,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America, Department of Surgery, Duke University, Durham, NC, United States of America
⨯
Kelly L. Barton,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Kristin Schroeder,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America
⨯
Katherine L. Misuraca,

Affiliation Graduate Program in Molecular Cancer Biology, Duke University, Durham, NC, United States of America
⨯
Christine Hoeman,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Alex Chung,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Donna M. Crabtree,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Francisco J. Cordero,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Raj Singh,

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America
⨯
Ivan Spasojevic,

Affiliations Department of Medicine—Oncology, Duke University, Durham, NC, United States of America, Duke Cancer Institute, Pharmaceutical Services—PK/PD Core Laboratory, Durham, NC, United States of America
⨯
Noah Berlow,

Affiliation Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, United States of America
⨯
Ranadip Pal,

Affiliation Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, United States of America
⨯
Oren J. Becher

* E-mail: oren.becher@duke.edu

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America, Department of Pathology, Duke University Medical Center, Durham, NC, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America
⨯

A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

Kyle G. Halvorson,
Kelly L. Barton,
Kristin Schroeder,
Katherine L. Misuraca,
Christine Hoeman,
Alex Chung,
Donna M. Crabtree,
Francisco J. Cordero,
Raj Singh,
Ivan Spasojevic

Published: March 6, 2015
https://doi.org/10.1371/journal.pone.0118926

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Genetic engineering
Is the Subject Area "Genetic engineering" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Brainstem
Is the Subject Area "Brainstem" applicable to this article?

Thanks for your feedback.
Neurospheres
Is the Subject Area "Neurospheres" applicable to this article?

Thanks for your feedback.
Pharmaceutical engineering
Is the Subject Area "Pharmaceutical engineering" applicable to this article?

Thanks for your feedback.