A Kinetic Study of the Main Guaco Metabolites Using Syrup Formulation and the Identification of an Alternative Route of Coumarin Metabolism in Humans

Open Access

Peer-reviewed

Research Article

João Cleverson Gasparetto,

Affiliation Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil
⨯
Rosângela Gonçalves Peccinini,

Affiliation Department of Natural Active Principles and Toxicology, Universidade Estadual Paulista Julio de Mesquita Filho, Araraquara, SP, Brazil
⨯
Thais Martins Guimarães de Francisco,

Affiliation Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil
⨯
Letícia Bonâncio Cerqueira,

Affiliation Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil
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Francinete Ramos Campos,

Affiliation Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil
⨯
Roberto Pontarolo

* E-mail: pontarolo@ufpr.br

Affiliation Department of Pharmacy, Universidade Federal do Paraná, Curitiba, PR, Brazil
⨯

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Coumarins
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Blood plasma
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Metabolites
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Drug metabolism
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Pharmacokinetics
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Acetonitrile
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Liquid-liquid extraction
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Quality control
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