Spatial Positioning of All 24 Chromosomes in the Lymphocytes of Six Subjects: Evidence of Reproducible Positioning and Spatial Repositioning following DNA Damage with Hydrogen Peroxide and Ultraviolet B

Dimitrios Ioannou; Lakshmi Kandukuri; Ameer Quadri; Victor Becerra; Joe Leigh Simpson; Helen G. Tempest

doi:10.1371/journal.pone.0118886

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Peer-reviewed

Research Article

Spatial Positioning of All 24 Chromosomes in the Lymphocytes of Six Subjects: Evidence of Reproducible Positioning and Spatial Repositioning following DNA Damage with Hydrogen Peroxide and Ultraviolet B

Dimitrios Ioannou ,

Contributed equally to this work with: Dimitrios Ioannou, Helen G. Tempest

Affiliation Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
⨯
Lakshmi Kandukuri,

Current address: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, India

Affiliation Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
⨯
Ameer Quadri,

Affiliation Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
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Victor Becerra,

Affiliation Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
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Joe Leigh Simpson,

Affiliations Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America, March of Dimes Foundation, White Plains, New York, United States of America
⨯
Helen G. Tempest

Contributed equally to this work with: Dimitrios Ioannou, Helen G. Tempest

* E-mail: htempest@fiu.edu

Affiliations Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America, Biomolecular Sciences Institute, Florida International University, Miami, Florida, United States of America
⨯

Spatial Positioning of All 24 Chromosomes in the Lymphocytes of Six Subjects: Evidence of Reproducible Positioning and Spatial Repositioning following DNA Damage with Hydrogen Peroxide and Ultraviolet B

Dimitrios Ioannou,
Lakshmi Kandukuri,
Ameer Quadri,
Victor Becerra,
Joe Leigh Simpson,
Helen G. Tempest

Published: March 10, 2015
https://doi.org/10.1371/journal.pone.0118886

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Lymphocytes
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DNA damage
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DNA repair
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Chromosome structure and function
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