Lincosamide Synthetase—A Unique Condensation System Combining Elements of Nonribosomal Peptide Synthetase and Mycothiol Metabolism

Jiri Janata; Stanislav Kadlcik; Marketa Koberska; Dana Ulanova; Zdenek Kamenik; Petr Novak; Jan Kopecky; Jitka Novotna; Bojana Radojevic; Kamila Plhackova; Radek Gazak; Lucie Najmanova

doi:10.1371/journal.pone.0118850

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Open Access

Peer-reviewed

Research Article

Lincosamide Synthetase—A Unique Condensation System Combining Elements of Nonribosomal Peptide Synthetase and Mycothiol Metabolism

Jiri Janata ,

* E-mail: janata@biomed.cas.cz

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Stanislav Kadlcik,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Marketa Koberska,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Dana Ulanova,

Affiliations Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic, Oceanography Section, Science Research Center, Kochi University, IMT-MEXT, Kohasu, Oko-cho, Nankoku, Kochi, 783–8505, Japan
⨯
Zdenek Kamenik,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Petr Novak,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Jan Kopecky,

Current address: Crop Research Institute, Drnovska 507, 142 20 Prague 6, Czech Republic

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Jitka Novotna,

Current address: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 166 10 Prague 6, Czech Republic

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Bojana Radojevic,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Kamila Plhackova,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Radek Gazak,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯
Lucie Najmanova

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic
⨯

Lincosamide Synthetase—A Unique Condensation System Combining Elements of Nonribosomal Peptide Synthetase and Mycothiol Metabolism

Jiri Janata,
Stanislav Kadlcik,
Marketa Koberska,
Dana Ulanova,
Zdenek Kamenik,
Petr Novak,
Jan Kopecky,
Jitka Novotna,
Bojana Radojevic,
Kamila Plhackova

Published: March 5, 2015
https://doi.org/10.1371/journal.pone.0118850

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Mutant strains
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Amide bonds
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